excision repair


excision repair
Mechanism for the repair of environmental damage to one strand of DNA (loss of purines due to thermal fluctuations, formation of pyrimidine dimers by UV irradiation). The site of damage is recognized, excised by an endonuclease, the correct sequence is copied from the complementary strand by a polymerase and the ends of this correct sequence are joined to the rest of the strand by a ligase. The term is sometimes restricted to bacterial systems where the polymerase also acts as endonuclease.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

  • Excision repair — is a term applied to several DNA repair mechanisms.Excision repair mechanisms that remove the damaged nucleotide replacing it with an undamaged nucleotide complementary to the nucleotide in the undamaged DNA strand. These include: *Base excision… …   Wikipedia

  • excision repair — dark repair (см.). (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • excision repair — noun An enzymatic DNA repair process in which a mismatching DNA sequence is removed, the gap being filled by synthesis of a new sequence complementary to the remaining strand • • • Main Entry: ↑excise …   Useful english dictionary

  • excision repair — excision repair. См. эксцизионная репарация. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • excision repair — DNA repair processes that involve the removal of a damaged or incorrect segment of one strand of double stranded DNA and its replacement by the synthesis of a new segment using the complementary strand of DNA as template …   Glossary of Biotechnology

  • Excision repair cross-complementing — (ERCC) is a set of proteins which are involved in DNA repair.The genes include: Gene|ERCC1, ERCC2 , Gene|ERCC3, Gene|ERCC4, Gene|ERCC5, Gene|ERCC6, and Gene|ERCC8.Members 6 and 8 are associated with Cockayne syndrome …   Wikipedia

  • Nucleotide excision repair — Diagram[1] Nucleotide excision repair is a DNA repair mechanism.[2] DNA constantly requires r …   Wikipedia

  • Base excision repair — (BER) is a cellular mechanism that repairs damaged DNA throughout the cell cycle. Repairing DNA sequence errors is necessary so that mutations are not propagated or to remove lesions that may lead to breaks in the DNA during replication.Single… …   Wikipedia

  • Base excision repair — Réparation par excision de base La réparation par excision de base (ou BER pour Base excision repair en anglais) est un mécanisme de réparation d un dommage au niveau d’une base individuelle de l’ADN. Un tel dommage est réparé par simple… …   Wikipédia en Français

  • nucleotide excision repair — (NER) repair of bulky lesions introduced into DNA by damage, such as that induced by ultraviolet light; at least 30 proteins are involved and the process consists of recognition of the lesion, strand separation at the site, single strand incision …   Medical dictionary


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