endothelins
(= ET-1, ET-2, ET-3)
Group of peptide hormones (all 21 residues) released by endothelial cells. All have two disulphide bridges that hold them in a conical spiral shape. They are the most potent vasoconstrictor hormones known. Structurally related to the snake venom sarafotoxins. Pre-pro-endothelin-1 (203 residues) is cleaved to the biologically inactive big endothelin-1 (92 residues) by endothelin converting enzyme which will further cleave big endothelin to form active endothelin-1. ET-1, the predominant form, is produced by endothelial cells, ET-2 and ET-3 by various tissues. In addition to their vasoconstrictive properties, endothelins have inotropic and mitogenic properties, influence salt and water balance, alter central and peripheral sympathetic activity and stimulate the renin-angiotensin-aldosterone system. Though ET-1 acting through endothelin receptor(A) is vasoconstrictive, it acts through ET(B) to induce the release of nitric oxide which is a vasodilator.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

  • Endothelin — protein Name = Endothelin 2 width = caption = Symbol = EDN2 AltSymbols = ATC prefix= ATC suffix= ATC supplemental= CAS number= CAS supplemental= DrugBank= EntrezGene = 1907 HGNCid =3177 OMIM = 131241 PDB = RefSeq = NM 001956 UniProt = P20800… …   Wikipedia

  • CMA1 — Chymase 1, mast cell, also known as CMA1, is a human gene. PBB Summary section title = summary text = This gene product is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to… …   Wikipedia

  • Endothelin 3 — Endothelin 3, also known as EDN3, is a human gene.cite web | title = Entrez Gene: EDN3 endothelin 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=1908| accessdate = ] PBB Summary section title = summary… …   Wikipedia

  • Endothelin — 1 Kugelmodell nach PDB  …   Deutsch Wikipedia

  • Endothelin-Rezeptorantagonist — Endothelin 1 Kugelmodell nach PDB  …   Deutsch Wikipedia

  • Cerebral aneurysm — Classification and external resources Diagram of cerebral aneurysm. ICD 10 I …   Wikipedia

  • Endothelin receptor type B — Endothelin receptor type B, also known as EDNRB, is a human gene.Endothelin receptor type B is a G protein coupled receptor which activates a phosphatidylinoitol calcium second messenger system. Its ligand, endothelin, consists of a family of… …   Wikipedia

  • Endothelin-Converting Enzyme — Endothelin konvertierendes Enzym 1 Größe 770 Aminosäuren Struktur Homodimer, single pass Typ 2 Membranprotein Kofaktor …   Deutsch Wikipedia

  • Endothelin-konvertierendes Enzym — 1 Masse/Länge Primärstruktur 770 Aminosäuren …   Deutsch Wikipedia

  • sarafotoxin — Group of snake cardiotoxic venoms from Atractaspis engaddensis. Structurally related to the endothelins …   Dictionary of molecular biology

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”