endothelin receptor
There are thought to be two G-protein coupled receptors for endothelin, ET(A) (427 residues) and ET(B) (427 residues in human), present on vascular smooth muscle cells mediating vasoconstriction, and on endothelium mediating nitric oxide release. ET(A) binds ET-1 preferentially whereas ET(B) binds ET-1, ET-2 and ET-3 with equal affinity.

Dictionary of molecular biology. 2004.

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  • Endothelin receptor — protein Name=endothelin receptor type A caption= width= HGNCid=3179 Symbol=EDNRA AltSymbols= EntrezGene=1909 OMIM=131243 RefSeq=NM 001957 UniProt=P25101 PDB= ECnumber= Chromosome=4 Arm=q Band=31.2 LocusSupplementaryData=protein Name=endothelin… …   Wikipedia

  • Endothelin receptor type B — Endothelin receptor type B, also known as EDNRB, is a human gene.Endothelin receptor type B is a G protein coupled receptor which activates a phosphatidylinoitol calcium second messenger system. Its ligand, endothelin, consists of a family of… …   Wikipedia

  • Endothelin receptor type A — Endothelin receptor type A, also known as EDNRA, is a human gene which encodes a G protein coupled receptor.cite web | title = Entrez Gene: EDNRA endothelin receptor type A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene… …   Wikipedia

  • Endothelin receptor antagonist — A endothelin receptor antagonist (ERA) is a drug which blocks endothelin receptors. Two main kinds of ERAs exist: * selective ERA (e.g. sitaxsentan), which affect endothelin A. * dual ERAs,(e.g. bosentan) which affect both endothelin A and B . [… …   Wikipedia

  • endothelin receptor antagonist — A drug that blocks the hormone endothelin and may prevent prostate cancer from spreading to the bones. It may also prevent the growth and spread of other types of cancer, including colorectal cancer …   English dictionary of cancer terms

  • Endothelin 3 — Endothelin 3, also known as EDN3, is a human gene.cite web | title = Entrez Gene: EDN3 endothelin 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=1908| accessdate = ] PBB Summary section title = summary… …   Wikipedia

  • Endothelin — protein Name = Endothelin 2 width = caption = Symbol = EDN2 AltSymbols = ATC prefix= ATC suffix= ATC supplemental= CAS number= CAS supplemental= DrugBank= EntrezGene = 1907 HGNCid =3177 OMIM = 131241 PDB = RefSeq = NM 001956 UniProt = P20800… …   Wikipedia

  • Receptor antagonist — This article is about the biochemistry term. For other uses, see Antagonist (disambiguation). Antagonists will block the binding of an agonist at a receptor molecule, inhibiting the signal produced by a receptor agonist coupling. A receptor… …   Wikipedia

  • endothelin-1 protein receptor antagonist — A substance that blocks the binding of the endothelin 1 protein to its receptor. Endothelin 1 is a small molecule that causes changes in blood vessels and helps regulate blood pressure. It can also stimulate the growth of some types of cells …   English dictionary of cancer terms

  • NK1 receptor antagonist — Neurokinin 1 (NK1) antagonists are a novel class of medications that possesses unique antidepressant,[1] anxiolytic,[2] and antiemetic properties. The discovery of neurokinin 1 (NK1) receptor antagonists was a turning point in the prevention of… …   Wikipedia

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