endogenous pyrogen
Fever-producing substance released by leucocytes (and Kuppfer cells in particular) that acts on the hypothalamic thermoregulatory centre. Now known to be interleukin 1.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

  • endogenous pyrogen — (en doj e nus pi ro jen) A substance such as the lymphokine interleukin 1, which is produced by host cells and induces a fever response in the host. It also is called simply a pyrogen …   Dictionary of microbiology

  • endogenous pyrogen — fever producing subtances produced by the macrophages or other cells in response to infection or to events inducing cell mediated immunity; included are interleukin 1 and tumor necrosis factor …   Medical dictionary

  • pyrogen — Substance or agent that produces fever. The major endogenous pyrogen in mammals is probably interleukin 1 …   Dictionary of molecular biology

  • pyrogen — A fever inducing agent; pyrogens are produced by bacteria, molds, viruses, and yeasts. [pyro + G. gen, producing] endogenous p. (EP) proteins that induce fever. Several (about 11) have been identified, including cytokines formed by components of… …   Medical dictionary

  • exogenous pyrogen — a fever producing agent of external origin; types include bacterial endotoxins and other microbial products, certain types of antigen antibody complexes, viruses, synthetic polynucleotides, incompatible blood and blood products, and androgen… …   Medical dictionary

  • Interleukin 1 — protein Name = interleukin 1, alpha caption = Crystal structure of IL 1a (PDB|2ILA). width = 250 HGNCid = 5991 Symbol = IL1A AltSymbols = IL1; IL 1A; IL1; IL1 ALPHA; IL1F1 EntrezGene = 3552 OMIM = 147760 RefSeq = NM 000575 UniProt = P01583 PDB =… …   Wikipedia

  • EP — Abbreviation for endogenous pyrogen. * * * echo planar; ectopic pregnancy; edible portion; electronic palpation; electrophoresis; electrophysiologic; electroprecipitin; emergency physician; emergency procedure; endocochlear potential; endogenous… …   Medical dictionary

  • interleukin-1 — (= IL 1) Protein (17 kD: 152 amino acids) secreted by macrophages or accessory cells involved in the activation of both T and B lymphocytes in response to antigens or mitogens, as well as affecting a wide range of other cell types. At least two… …   Dictionary of molecular biology

  • Drug-induced fever — is a state wherein the administration of drugs intended to help a patient causes a fever. The drug may interfere with heat dissipation peripherally, increase the rate of metabolism, evoke a cellular or humoral immune response, mimic endogenous… …   Wikipedia

  • lipopolysaccharide — The major constituents of the cell walls of Gram negative bacteria. Highly immunogenic and stimulates the production of endogenous pyrogen interleukin 1 and tumour necrosis factor (TNF) …   Dictionary of molecular biology

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”