elongation factor
Peptidyl transferase components of ribosomes that catalyse formation of the acyl bond between the incoming amino acid residue and the peptide chain. There are three classes of elongation factor: EF1 a (EF-Tu in prokaryotes) binds GTP and aminoacyl-tRNA, delivering it to the A site of ribosomes. EF-1 b (EF-Ts) helps in regeneration of GTP-EF-1 a. EF-2 (EF-G) binds GTP and peptidyl-tRNA and translocates it from the A site to the P site. Diphtheria toxin inhibits protein synthesis in eukaryotes by adding an ADP-ribosyl group to a modified histidine residue (diphthamide) in elongation factor II.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

  • Elongation factor — Elongation factors are a set of proteins that facilitate the events of translational elongation, the steps in protein synthesis from the formation of the first peptide bond to the formation of the last one.Elongation is the most rapid step in… …   Wikipedia

  • elongation factor — elongation factor. См. фактор элонгации [EF G у прокариот]. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • elongation factor — one of two soluble proteins (EF 1 and EF 2) involved in the addition of each amino acid to the growing polypeptide chain in protein synthesis (see translation) …   Medical dictionary

  • Elongation factor 2 kinase — In enzymology, an elongation factor 2 kinase (EC number|2.7.11.20) is an enzyme that catalyzes the chemical reaction:ATP + [elongation factor 2] ightleftharpoons ADP + [elongation factor 2] phosphateThus, the two substrates of this enzyme are ATP …   Wikipedia

  • Negative elongation factor — NELF (Negative elongation factor) is a four subunit protein (NELF A, NELF B, NELF C or NELF D, NELF E) that affects transcription by RNA polymerase II. Subunit NELF E is also known as RDBP.[1][2] The NELF A subunit is encoded by the gene WHSC2,… …   Wikipedia

  • Elongation (astronomy) — (For other uses of elongation, see Elongation) Elongation is an astronomical term that refers to the angle between the Sun and a planet, as viewed from Earth.When an inferior planet is visible after sunset, it is near its greatest eastern… …   Wikipedia

  • factor — 1. One of the contributing causes in any action. 2. One of the components that by multiplication makes up a number or expression. 3. SYN: gene. 4. A vitamin or other essential element. 5. An event, characteristic, or other definable entity that …   Medical dictionary

  • Prokaryotic elongation factors — In prokaryotes, three elongation factors are required for translation: EF Tu, EF Ts, and EF G. EF Tu The prokaryotic factor EF Tu (elongation factor thermo unstable) mediates the entry of the aminoacyl tRNA into a free site of the ribosome. EF Tu …   Wikipedia

  • Transcription elongation regulator 1 — Transcription elongation regulator 1, also known as TCERG1, is a human gene.cite web | title = Entrez Gene: TCERG1 transcription elongation regulator 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=10915| …   Wikipedia

  • Ribosome Recycling Factor — protein Name = mitochondrial ribosome recycling factor caption = width = HGNCid = 7234 Symbol = MRRF AltSymbols = EntrezGene = 92399 OMIM = 604602 RefSeq = NM 138777 UniProt = Q96E11 PDB = ECnumber = Chromosome = 9 Arm = q Band = 32… …   Wikipedia

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