dyrk
Dual-specificity protein kinase regulated by tyrosine phosphorylation that may regulate cell cycle. Also has nuclear targeting signal, putative leucine zipper and a very conserved 13-histidine repeat sequence. Rat gene dyrk is a homologue of Drosophila minibrain ( mnb ) a gene involved in postembryonic neurogenesis. Human homologue maps to Chromosome 21 and may be involved in pathogenesis of certain phenotypes of Down&’s syndrome.

Dictionary of molecular biology. 2004.

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