down-regulation
Reduction in the responsiveness of a cell to a stimulus following first exposure, often by a reduction in the number of receptors expressed on the surface (as a consequence of reduced recycling). Tends to be used imprecisely.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

  • down-regulation — Development of a refractory or tolerant state consequent upon repeated administration of a pharmacologically or physiologically active substance; often accompanied by an initial decrease in affinity of receptors for the agent and a subsequent… …   Medical dictionary

  • Regulation of gene expression — Gene modulation redirects here. For information on therapeutic regulation of gene expression, see therapeutic gene modulation. For vocabulary, see Glossary of gene expression terms Diagram showing at which stages in the DNA mRNA protein pathway… …   Wikipedia

  • Down-Regulierung — Als Herabregulation (Englisch: Down Regulation) bezeichnet man die durch eine anhaltend hohe Liganden Konzentration ausgelöste Verminderung der Anzahl von Rezeptoren auf einer Zelle, einschließlich des Abbaus der Rezeptoren. Bei Rezeptoren Mangel …   Deutsch Wikipedia

  • down — I. /daʊn / (say down) adverb 1. from higher to lower; in descending direction or order; into or in a lower position or condition. 2. on or to the ground. 3. to a point of submission, inactivity, etc. 4. to or in a position spoken of as lower, as… …   Australian English dictionary

  • Regulation C — A regulation that implements the Home Mortgage Disclosure Act of 1975. Regulation C mandates that depository institutions must annually disclose the communities to which they provided residential mortgages. This allows regulatory authorities to… …   Investment dictionary

  • up-regulation — Opposite of down regulation …   Medical dictionary

  • Neural top down control of physiology — concerns the direct regulation by the brain of physiological functions (in addition to smooth muscle and glandular ones). Cellular functions include the immune system’s production of T lymphocytes and antibodies, and nonimmune related homeostatic …   Wikipedia

  • Customs Regulation 3295/94 — EU regulation title=Regulation laying down measures to prohibit the release for free circulation, export, re export or entry for a suspensive procedure of counterfeit and pirated goods number= (EC) No 3295/94 madeby=European Council madeunder=Art …   Wikipedia

  • Bureau of Ocean Energy Management, Regulation and Enforcement — Agency overview Formed January 19, 1982 (1982 01 19) Headquarters Washington, D.C. Employees 1,614 (2009) Annual budget …   Wikipedia

  • European Company Regulation — Companies law Company  …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”