dihydrofolate reductase
(= DHFR)
An enzyme (EC 1.5.1.3) involved in the biosynthesis of folic acid coenzymes, that transfers hydrogen from NADP to dihydrofolate, yielding tetrahydrofolic acid, an essential vitamin cofactor in purine, thymidine and methionine synthesis. Inhibitors (eg. aminopterin and amethopterin, components of HAT medium) can be used as antimicrobial and anticancer drugs.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

  • Dihydrofolate reductase — Ribbon diagram of human dihydrofolate reductase in complex with folate (blue). From PDB 1DRF …   Wikipedia

  • Dihydrofolate réductase — Structure de la DHFR complexée au folate (à gauche) et au NADPH (à droite) …   Wikipédia en Français

  • dihydrofolate reductase — dihydrofolate reductase. См. дигидрофолатредуктаза. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • dihydrofolate reductase — An enzyme reversibly oxidizing tetrahydrofolate to 7,8 dihydrofolate with NADP+. A crucial enzyme in one carbon metabolism; used as a marker of drug resistance to methotrexate. SYN: 5,6,7,8 tetrahydrofolate dehydrogenase. * * * di·hy·dro·fo·late… …   Medical dictionary

  • Dihydrofolate reductase inhibitor — A dihydrofolate reductase inhibitor is a molecule that inhibits the function of dihydrofolate reductase, and is a type of antifolate. Since folate is needed by rapidly dividing cells to make thymine, this effect may be used to therapeutic… …   Wikipedia

  • dihydrofolate reductase inhibitor — any of various drugs that interfere with the conversion of folic acid to its active form in the body. They include pyrimethamine, trimethoprim, triamterene, and methotrexate. When such drugs are necessary, folate deficiency is treated with… …   Medical dictionary

  • dihydrofolate reductase inhibitor — any of various drugs that interfere with the conversion of folic acid to its active form in the body. They include pyrimethamine, trimethoprim, and methotrexate. When such drugs are necessary, folate deficiency is treated with folinic acid rather …   The new mediacal dictionary

  • Ингибитор Дигидрофолат Редуктазы (Dihydrofolate Reductase Inhibitor) — лекарственное вещество, влияющее на превращение фолиевой кислоты в ее активную форму в организме человека. К этим веществам относятся: пириметамин, триметоприм, триамтерен и метотрексат. Когда больному назначаются эти лекарства, то для устранения …   Медицинские термины

  • Reductase — Réductase Une réductase est une enzyme qui diminue l énergie d activation d une réaction d oxydo réduction. Exemples 5 alpha réductase, enzyme du métabolisme de la testostérone, cytochrome b5 réductase Folate et Dihydrofolate réductase HMG CoA… …   Wikipédia en Français

  • Dihydrofolate — Vitamine B9 Vitamine B9 Structure chimique de la vitamine B9 Général Synonymes acide folique vitamine M fola …   Wikipédia en Français

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