(= CD148; HPTPe;)
Density-enhanced phosphatase-1 (220-250 kD). Transmembrane protein with eight extracellular FnIII domains and a single cytoplasmic tyrosine phosphatase domain. Dep-1 is involved in signal transduction in lymphocytes and is also found in smooth muscle cells and tumour cells. When clustered Dep-1 inhibits Fc g RII-induced superoxide production. In many tumour cells Dep-1 is associated with a 64 kD serine/threonine kinase that may regulate its activity. Has been speculated to play a role in density-dependent inhibition of growth.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

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  • dep — abbrev. 1. department 2. departs 3. departure 4. deposed 5. deposit 6. deputy * * * …   Universalium

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  • dep|o|si|tion — «DEHP uh ZIHSH uhn, DEE puh », noun. 1. the act of putting out of office or a position of authority; removal from power. 2. a) the giving of testimony under oath. b) the testimony so given, especially a sworn statement in writing: »The prisoner… …   Useful english dictionary

  • dep|re|cate — «DEHP ruh kayt», transitive verb, cat|ed, cat|ing. 1. to express strong disapproval of; plead against; protest against: »Lovers of peace deprecate war. 2. to belittle; disparage: »It must take an unusual amount of moxie to deprecate Richard… …   Useful english dictionary

  • dep|re|ca|tion — «DEHP ruh KAY shuhn», noun. 1. a strong expression of disapproval; pleading or protesting against something: »a look of deprecation (George Eliot). 2. belittling; disparagement: »Granted all the evils of colonialism, there has been too much… …   Useful english dictionary

  • dep|re|ca|to|ry — «DEHP ruh kuh TR ee, TOHR », adjective. 1. deprecating. 2. = apologetic. (Cf. ↑apologetic) …   Useful english dictionary

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