deacetylase
An enzyme that removes an acetyl group: one of the most active deacetylation reactions is the constant deacetylation (and reacetylation) of lysyl residues in histones (the half life of an acetyl group may be as low as 10min). Acetylation (which removes a positive charge on the lysine e -amino group) is thought to be increased in active genes, therefore deacetylation would be important in switching off genes.

Dictionary of molecular biology. 2004.

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  • deacetylase — noun Any of several classes of enzyme that remove acetyl groups from proteins …   Wiktionary

  • Histone deacetylase 2 — Histone deacetylase 2, also known as HDAC2, is a human gene. PBB Summary section title = summary text = This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes and… …   Wikipedia

  • Histone deacetylase — Histone deacetylases (HDAC) (EC number 3.5.1) are a class of enzymes that remove acetyl groups from an ε N acetyl lysine amino acid on a histone. Its action is opposite to that of histone acetyltransferase.ubtypesHDAC proteins are found in three… …   Wikipedia

  • Histone deacetylase 5 — Histone deacetylase 5, also known as HDAC5, is a human gene.cite web | title = Entrez Gene: HDAC5 histone deacetylase 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=10014| accessdate = ] PBB Summary… …   Wikipedia

  • Histone deacetylase inhibitor — Histone deacetylase inhibitors (HDAC inhibitors, HDI) are a class of compounds that interfere with the function of histone deacetylase.Cellular Biochemistry / PharmacologyTo carry out gene expression, a cell must control the coiling and uncoiling …   Wikipedia

  • N-acetylgalactosaminoglycan deacetylase — Identifiers EC number 3.1.1.58 CAS number 52410 59 0 …   Wikipedia

  • N-acetylglucosamine-6-phosphate deacetylase — Identifiers EC number 3.5.1.25 CAS number 9027 50 3 …   Wikipedia

  • N-acetylglucosaminylphosphatidylinositol deacetylase — Identifiers EC number 3.5.1.89 Databases IntEnz …   Wikipedia

  • Histon-Deacetylase — Vorhandene Strukturdaten …   Deutsch Wikipedia

  • Acetylspermidine deacetylase — In enzymology, an acetylspermidine deacetylase (EC number|3.5.1.48) is an enzyme that catalyzes the chemical reaction:N8 acetylspermidine + H2O ightleftharpoons acetate + spermidineThus, the two substrates of this enzyme are N8 acetylspermidine… …   Wikipedia

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