cytohesin-1
(= B2-1)
Guanine nucleotide exchange factor for human ADP-ribosylation factor (ARF) GTPases. Abundant in cells of the immune system where it mediates PI3-kinase activation of b 2 integrin (particularly LFA-1) through interaction with the cytoplasmic domain. Closely related to ARNO and GRP-1; all three have a central Sec7-like domain and C-terminal pleckstrin homology (PH) domain. The PH domain and C-terminal polybasic sequence are important for membrane-association and function.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

  • GRP-1 — Guanine nucleotide exchange factor with PH domain that binds PtdIns(3,4,5) P3 and also has domain with homology to yeast Sec7. See cytohesin, ARNO, Gea 1 and Gea 2, other members of the family …   Dictionary of molecular biology

  • Gea-1 — GEF (guanine nucleotide exchange factor) for ARF from Saccharomyces cerevisiae. Contains Sec7 like domain. Similar to ARNO and cytohesin …   Dictionary of molecular biology

  • PSCD1 — Pleckstrin homology, Sec7 and coiled coil domains 1(cytohesin 1), also known as PSCD1, is a human gene.cite web | title = Entrez Gene: PSCD1 pleckstrin homology, Sec7 and coiled coil domains 1(cytohesin 1)| url =… …   Wikipedia

  • PSCD2 — Pleckstrin homology, Sec7 and coiled coil domains 2 (cytohesin 2), also known as PSCD2, is a human gene.cite web | title = Entrez Gene: PSCD2 pleckstrin homology, Sec7 and coiled coil domains 2 (cytohesin 2)| url =… …   Wikipedia

  • PSCDBP — Pleckstrin homology, Sec7 and coiled coil domains, binding protein, also known as PSCDBP, is a human gene.cite web | title = Entrez Gene: PSCDBP pleckstrin homology, Sec7 and coiled coil domains, binding protein| url =… …   Wikipedia

  • PSCD4 — Pleckstrin homology, Sec7 and coiled coil domains 4, also known as PSCD4, is a human gene.cite web | title = Entrez Gene: PSCD4 pleckstrin homology, Sec7 and coiled coil domains 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene… …   Wikipedia

  • PSCD3 — Pleckstrin homology, Sec7 and coiled coil domains 3, also known as PSCD3, is a human gene.cite web | title = Entrez Gene: PSCD3 pleckstrin homology, Sec7 and coiled coil domains 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene… …   Wikipedia

  • CD18 — Integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) PDB rendering based on 1l3y …   Wikipedia

  • ARF1 — ADP ribosylation factor 1, also known as ARF1, is a human gene. PBB Summary section title = summary text = ADP ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide binding… …   Wikipedia

  • RIMS1 — Regulating synaptic membrane exocytosis 1, also known as RIMS1, is a human gene.cite web | title = Entrez Gene: RIMS1 regulating synaptic membrane exocytosis 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView… …   Wikipedia

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