cytochalasins
A group of fungal metabolites that inhibit the addition of G-actin to a nucleation site and therefore perturb labile microfilament arrays. Cytochalasin B inhibits at around 1 m g/ml but at about 5 m g/ml begins to inhibit glucose transport. Cytochalasin D affects only the microfilament system and is therefore preferable.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

  • cytochalasins — A group of substances derived from molds that disaggregate the microfilaments of the cell and interfere with the division of cytoplasm, inhibit cell movement, and cause extrusion of the nucleus; used for investigations in cell …   Medical dictionary

  • Cytochalasin — Cytochalasins are fungal metabolites that have the ability to bind to actin filaments and block polymerization and the elongation of actin. As a result of the inhibition of actin polymerization, cytochalasins can change cellular morphology,… …   Wikipedia

  • Цитохалазины — (от Цито... и греч. chálasis расслабленность)         группа родственных антибиотиков, продуцируемых различными несовершенными грибами (См. Несовершенные грибы).                   R1, R2 различные радикалы         Выделены в 1967 английскими… …   Большая советская энциклопедия

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  • Actin-binding protein — Actin binding proteins (also known as ABP) are proteins that bind to actin. This may mean ability to bind actin monomers, or polymers, or both.Many actin binding proteins, including α actinin, β spectrin, dystrophin, utrophin and fimbrin, do this …   Wikipedia

  • Cytochalasin D — Other names Zygosporin A; Cytohalasin D; Lygosporin A Ide …   Wikipedia

  • Citocalasina D — La citocalasina D es un metabolito de origen fúngico capaz, como todas las citocalasinas, de unirse a filamentos de actina y, por ello, impedir su polimerización y elongación. Por ello, repercuten en la morfología celular e inhiben procesos… …   Wikipedia Español

  • chaetoglobosins — Chaetoglobosin J is a fungal metabolite related to cytochalasins that will inhibit elongation at the barbed end of an actin microfilament. Chaetoglobosin A is produced by Chaetomium globosum. Chaetoglobosin K is a plant growth inhibitor and toxin …   Dictionary of molecular biology

  • micropinocytosis — Pinocytosis of small vesicles (around 100nm in diameter). Not blocked by cytochalasins …   Dictionary of molecular biology

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