CTLA-4
(= CD152)
Type I transmembrane protein (20 kD) of the immunoglobulin superfamily. Found on activated T-cells and binds to CD80 on B-cells. Resembles CD28 but acts as a negative regulator of T-cell activation. Cytoplasmic domain interacts with SH2 domain of Shp2 (protein tyrosine phosphatase) and possibly with PI3-kinase. CTLA-4-deficient mice develop a severe lymphoproliferative disorder.

Dictionary of molecular biology. 2004.

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