combinatorial chemistry


combinatorial chemistry
Method by which large numbers of compounds can be made, usually utilizing solid-phase synthesis. In the simplest form carrier beads would be treated separately so as to couple subunits A, B, & C, mixed, re-divided, and then subunits A, B & C added in the three reaction mixtures. Thus bead +AA, AB, AC, BA, BB, BC etc would have been synthesized - though the products are mixed and deconvolution of an active mixture will be necessary to identify the active molecule. Using a relatively small number of reactions enormous diversity can rapidly be generated. Increasingly the term is used loosely for any procedure that generates highly diverse sets of compounds - the more recent tendency is to prefer high speed parallel synthesis in which each reaction chamber contains only one compound.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

  • Combinatorial chemistry — involves the rapid synthesis or the computer simulation of a large number of different but structurally related molecules or materials. It is especially common in CADD (Computer aided drug design) and can be done online with web based software,… …   Wikipedia

  • Combinatorial Chemistry — An Online Journal   Titre abrégé Comb. Chem. Discipline Chimie …   Wikipédia en Français

  • combinatorial chemistry — com·bi·na·to·ri·al chemistry .käm bə nə tōr ē əl , kəm .bī nə , tȯr n a branch of applied chemistry concerned with the rapid synthesis and screening of large numbers of different but related chemical compounds generated from a mixture of known… …   Medical dictionary

  • combinatorial chemistry — kombinatorinė chemija statusas T sritis chemija apibrėžtis Labai didelio skaičiaus mažų kiekių panašios sandaros junginių automatizuota sintezė ir savybių tyrimas mažos plokštelės celėse. atitikmenys: angl. combinatorial chemistry rus.… …   Chemijos terminų aiškinamasis žodynas

  • combinatorial chemistry — noun : a branch of applied chemistry concerned with the rapid synthesis and screening of large numbers of different but related chemical compounds generated from a mixture of known building blocks in order to recover new substances optimally… …   Useful english dictionary

  • combinatorial chemistry — noun the synthesis of a large number of structurally related compounds, especially in the pharmaceutical industry in an attempt to produce improved drugs …   Wiktionary

  • Combinatorial Chemistry & High Throughput Screening —   Titre abrégé Comb. Chem. High Throughput Screen. Discipline …   Wikipédia en Français

  • Journal of Combinatorial Chemistry —   Titre abrégé J. Comb. Chem. Discipline Chimie Langue …   Wikipédia en Français

  • Dynamic combinatorial chemistry — is defined as combinatorial chemistry under thermodynamic control.[1] Contents 1 Introduction 2 Current Applications 2.1 Medicine and Pharmaceutical …   Wikipedia

  • Journal of Combinatorial Chemistry — Infobox Journal discipline = Combinatorial chemistry abbreviation = J. Comb. Chem. website = http://pubs.acs.org/journals/jcchff/index.html publisher = American Chemical Society country = USA history = 1999 to present ISSN = 1520 4774The Journal… …   Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.