collagen
Major structural protein (285 kD) of extracellular matrix. An unusual protein both in amino acid composition (very rich in glycine (30%), proline, hydroxyproline, lysine, and hydroxylysine; no tyrosine or tryptophan), structure (a triple helical arrangement of 95 kD polypeptides giving a tropocollagen molecule, dimensions 300nm x 0.5nm), and resistance to proteases. Most types are fibril-forming with characteristic quarter-stagger overlap between molecules producing an excellent tension-resisting fibrillar structure. Type IV, characteristic of basal lamina does not form fibrils. Many different types of collagen are now recognized. Some are glycosylated (glucose-galactose dimer on the hydroxylysine), and nearly all types can be crosslinked through lysine side-chains. See dermatosparaxis, Ehlers-Danlos syndrome, scurvy.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

  • Collagen — is the principal protein of the skin, tendons, cartilage, bone and connective tissue. * * * The major protein (comprising over half of that in mammals) of the white fibers of connective tissue, cartilage, and bone, that is insoluble in water but… …   Medical dictionary

  • Collagen — Col la*gen, n. [Gr. ko lla glue + gen.] (Physiol. Chem.) The chemical basis of ordinary connective tissue, as of tendons or sinews and of bone. On being boiled in water it becomes gelatin or glue. [1913 Webster] …   The Collaborative International Dictionary of English

  • collagen — collagen. См. коллаген. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • Collagen — Collagen, Glutin (s.d.) gebendes Gewebe …   Pierer's Universal-Lexikon

  • collagen — structural protein of connective tissue, 1843, from Fr. collagène, from Gk. kolla glue + gen giving birth to (see GEN (Cf. gen)) …   Etymology dictionary

  • collagen — ► NOUN ▪ the main structural protein found in animal connective tissue, yielding gelatin when boiled. ORIGIN French collagène, from Greek kolla glue …   English terms dictionary

  • collagen — [käl′ə jən] n. [< Gr kolla, glue + GEN] a fibrous protein found in connective tissue, bone, and cartilage collagenic [käl′əjən′ik] adj. collagenous [kə laj′ə nəs] adj …   English World dictionary

  • Collagen — Tropocollagen triple helix Collagen /ˈkɒlədʒɨn/ is a group of naturally occurring proteins found in animals, especially in the flesh and connective tissues of mammals.[1] It is the main component of connectiv …   Wikipedia

  • collagen — collagenous /keuh laj euh neuhs/, adj. /kol euh jeuhn/, n. Biochem. any of a class of extracellular proteins abundant in higher animals, esp. in the skin, bone, cartilage, tendon, and teeth, forming strong insoluble fibers and serving as… …   Universalium

  • collagen — [[t]kɒ̱ləʤən[/t]] N UNCOUNT Collagen is a protein that is found in the bodies of people and animals. It is often used as an ingredient in cosmetics or is injected into the face in cosmetic surgery, in order to make the skin look younger. The… …   English dictionary

  • Collagen — Kollagen (internationalisierte Schreibweise Collagen; Betonung auf der letzten Silbe) ist ein nur bei Menschen und Tieren vorkommendes Strukturprotein des Bindegewebes (genauer: der extrazellulären Matrix). Im menschlichen Körper ist Kollagen mit …   Deutsch Wikipedia

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