clonal selection


clonal selection
The process whereby one or more clones, ie. cells expressing a particular gene sequence are selected by naturally-occurring processes from a mixed population. Generally the clonal selection is for general expansion by mitosis, particularly with reference to B-lymphocytes where selection with subsequent expansion of clones occurs as a result of antigenic stimulation only of those lymphocytes bearing the appropriate receptors.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

  • Clonal selection — of lymphocytes: 1) A hematopoietic stem cell undergoes differentiation and genetic rearrangement to produce 2) immature lymphocytes with many different antigen receptors. Those that bind to 3) antigens from the body s own tissues are destroyed,… …   Wikipedia

  • clonal selection — noun (biology) In a young mammal, the method of immunoglobulin production ensuring that there is a large lymphocyte population with a wide variety of antigen binding sites, so that when a foreign antigen binds to a lymphocyte it will stimulate… …   Useful english dictionary

  • clonal selection — The production of a population of plasma cells all producing the same antibody in response to the interaction between a B lymphocyte producing that specific antibody and the antigen bound by that antibody. See: primary immune response, secondary… …   Glossary of Biotechnology

  • clonal selection theory — clonal selection theory. См. клонально селекционная теория. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • Clonal Selection Algorithm — In Artificial immune systems, Clonal selection algorithms are a class of algorithms inspired by the clonal selection theory of acquired immunity that explains how B and T lymphocytes improve their response to antigens over time called affinity… …   Wikipedia

  • clonal selection theory — a modification of the natural selection theory (q.v.): there are in each adult several million clones of antibody producing cells, each programmed to make antibody of a single specificity and bearing cell surface receptors capable of reacting… …   Medical dictionary

  • Clonal — may refer to in Immunology Clonal deletion, a process by which B cells and T cells are deactivated before act significantly upon specific antigens Clonal selection theory, a model for how the immune system responds to infection Clonal anergy, a… …   Wikipedia

  • clonal deletion theory — a theory of immunologic tolerance to self antigens according to which “forbidden clones” of immunocytes, those reactive with self antigens, are eliminated on contact with antigen during fetal life. The terms “clonal abortion,” “clonal… …   Medical dictionary

  • clonal — ● clonal, clonale, clonaux adjectif Qui concerne le clone. clonal, ale, aux [klɔnal, o] adj. ÉTYM. 1961; de clone. → Clone. ❖ ♦ Biol. Relatif à un clone, aux clones, au clonage. || Sélection clo …   Encyclopédie Universelle

  • Selección clonal — Teoría de Selección Clonal Esta teoría postula que cada antígeno estimulará a aquel linfocito o grupo de linfocitos que poseen en su membrana receptores capaces de reconocer y unirse específicamente a él y que como consecuencia se producía su… …   Wikipedia Español


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