clonal deletion
One of the two main hypotheses advanced to explain the absence of autoimmune responses: now generally accepted. Clonal deletion is the programmed death of inappropriately stimulated, auto-reactive, clones of T cells.

Dictionary of molecular biology. 2004.

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  • Clonal deletion — is a process by which B cells and T cells are deactivated after they have expressed receptors for self antigens and before they develop into fully immunocompetent lymphocytes.[1] It is one method of immune tolerance. References ^ Lecture 15… …   Wikipedia

  • clonal deletion — noun (biology) The removal of potentially lethal clones specific for self antigens, one of the main ways in which self tolerance is achieved • • • Main Entry: ↑clone …   Useful english dictionary

  • clonal deletion theory — a theory of immunologic tolerance to self antigens according to which “forbidden clones” of immunocytes, those reactive with self antigens, are eliminated on contact with antigen during fetal life. The terms “clonal abortion,” “clonal… …   Medical dictionary

  • Clonal — may refer to in Immunology Clonal deletion, a process by which B cells and T cells are deactivated before act significantly upon specific antigens Clonal selection theory, a model for how the immune system responds to infection Clonal anergy, a… …   Wikipedia

  • Clonal anergy — For the use of anergy in thermodynamics, see Exergy. Anergy is a term in immunobiology that describes a lack of reaction by the body s defense mechanisms to foreign substances, and consists of a direct induction of peripheral lymphocyte tolerance …   Wikipedia

  • clonal selection theory — a modification of the natural selection theory (q.v.): there are in each adult several million clones of antibody producing cells, each programmed to make antibody of a single specificity and bearing cell surface receptors capable of reacting… …   Medical dictionary

  • Central tolerance — is the mechanism by which newly developing T cells and B cells are rendered non reactive to self[1]. The concept of central tolerance was proposed in 1959 by Joshua Lederberg[2], as part of his general theory of immunity and tolerance, and is… …   Wikipedia

  • Molecular mimicry — is defined as the theoretical possibility that sequence similarities between foreign and self peptides are sufficient to result in the cross activation of autoreactive T or B cells by pathogen derived peptides. Despite the promiscuity of several… …   Wikipedia

  • tolerance — 1. The ability to endure or be less responsive to a stimulus, especially over a period of continued exposure. 2. The power of resisting the action of a poison or of taking a drug continuously or in large doses without injurious effects. [L.… …   Medical dictionary

  • Autoimmunity — Infobox Disease Name = Autoimmunity Caption = DiseasesDB = 28805 ICD10 = ICD9 = ICD9|279.4 ICDO = OMIM = 109100 MedlinePlus = eMedicineSubj = eMedicineTopic = MeshID = D001327 Autoimmunity is the failure of an organism to recognize its own… …   Wikipedia

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