- cholesterol binding toxins
Family of 50-60 kD pore-forming toxins from various genera of bacteria including Streptococcus, Listeria, Bacillus and Clostridium. Apparently bind to cholesterol and oligomerise to form a pore: as a result cause cell lysis and are lethal. See Streptolysin O. Other examples include Pneumolysin from S. pneumoniae, Cereolysin O from Bacillus cereus, Thuringolysin O from B. thuringiensis, Tetanolysin from Clostridium tetani, Botulinolysin from C. botulinum, Perfringolysin O from C. perfringens, Listeriolysin O from L. monocytogenes.
Dictionary of molecular biology. 2004.
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