cholera toxin


cholera toxin
A multimeric protein toxin from Cholera vibrio. The toxic A subunit (27 kD) activates adenyl cyclase irreversibly by ADP-ribosylation of a Gs protein. The B subunit (57 kD) has 5 identical monomers, binds to GM1 ganglioside and facilitates passage of the A subunit across the cell membrane.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

  • Cholera toxin — (sometimes abbreviated to CTX, Ctx, or CT) is a protein complex secreted by the bacterium Vibrio cholerae.[1][2] CTX is responsible for the massive, watery diarrhea characteristic of cholera infection. Contents 1 Structure …   Wikipedia

  • Cholera-Toxin — Struktur des Choleratoxins, mit der Untereinheit A (rot) und der pentameren Untereinheit B (blau). Das Choleratoxin (CTX) ist ein von den Bakterien Vibrio cholerae und Vibrio eltor produziertes Toxin, das beim Menschen eine schwere… …   Deutsch Wikipedia

  • cholera toxin — an exotoxin produced by Vibrio cholerae; a protein enterotoxin that binds to the membrane of enteric cells and stimulates the adenylate cyclase system, causing the hypersecretion of chloride and bicarbonate ions seen in cholera. Called also… …   Medical dictionary

  • Cholera — Classification and external resources Scanning electron microscope image of Vibrio cholerae ICD 10 A …   Wikipedia

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  • Toxin — This article is about the class of poisonous substances. For other uses, see Toxin (disambiguation). Universal warning symbol used to indicate toxic substances or environments A toxin (from Ancient Greek: τοξικόν toxikon) is a poisonous… …   Wikipedia

  • cholera — choleraic /kol euh ray ik/, adj. /kol euhr euh/, n. 1. Also called Asiatic cholera. Pathol. an acute, infectious disease, endemic in India and China and occasionally epidemic elsewhere, characterized by profuse diarrhea, vomiting, cramps, etc. 2 …   Universalium

  • Cholera — A devastating and sometimes lethal disease with intense vomiting and profuse watery diarrhea leading to dehydration which, unless immediately treated, may be fatal. Cholera was discovered in 1883 to be due to infection with Vibrio cholerae, a… …   Medical dictionary

  • Toxin — One of a number of poisons produced by certain plants, animals, and bacteria. The term toxin is frequently used to refer specifically to a particular protein produced by some higher plants, animals and pathogenic (disease causing) bacteria. A… …   Medical dictionary

  • cholera enterotoxin — see under toxin …   Medical dictionary


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