An actin depolymerizing factor (ADF) (13-15 kD) from protozoa ( Toxoplasma gondii, Acanthamoeba castellanii ) that will sever actin filaments and sequester G actin. Binds ADP-G-actin with higher affinity than ATP-actin and binding is very sensitive to the divalent cation present on the actin. Has high sequence homology with vertebrate cofilin and destrin, echinoderm depactin and some plant ADFs but lacks the nuclear localization sequence found in the vertebrate ADFs.
Dictionary of molecular biology. 2004.