calpain
Calcium-activated cytoplasmic proteases containing the EF-hand motif. Calpain I is activated by micromolar calcium, Calpain II by millimolar calcium. Calpain has two subunits, the larger (80 kD) has 4 domains one homologous with papain, one with calmodulin, the smaller (30 kD) has one domain homologous with calmodulin. First isolated from erythrocytes, but now described from other cells.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

  • Calpain — Calpains (EC number|3.4.22.52, EC number|3.4.22.53) are a family of calcium dependent, non lysosomal cysteine proteases (proteolytic enzymes) expressed ubiquitously in mammals and many other organisms. Calpains constitute the C2 family of… …   Wikipedia

  • calpain — cal·pain (kalґpān) any of a group of related calcium activated proteases of eukaryotic cells, including calpain 1 [EC 3.4.22.52] and calpain 2 [EC 3.4.22.53]; they are implicated in cytoskeletal reorganization, membrane protein degradation,… …   Medical dictionary

  • calpain — cal·pain (kălʹpān ) n. A proteolytic enzyme that is regulated by the concentration of calcium ions.   [Probably calcium + protease + in.] * * * …   Universalium

  • calpain — noun Any of a family of enzymes that regulate calcium in the body …   Wiktionary

  • Calpain — Cal|pa|in [Kurzw. aus ↑ Calcium u. ↑ Papain], das; s, e; Syn.: Calcium Activated Factor (CAF): eine calciumabhängige, papainartig wirkende, körpereigene Proteinase …   Universal-Lexikon

  • CAPN10 — Calpain 10, also known as CAPN10, is a human gene. PBB Summary section title = summary text = Calpains are ubiquitous, well conserved family of calcium dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an… …   Wikipedia

  • CAPN1 — Calpain 1, (mu/I) large subunit, also known as CAPN1, is a human gene.cite web | title = Entrez Gene: CAPN1 calpain 1, (mu/I) large subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=823| accessdate =… …   Wikipedia

  • CAPNS1 — Calpain, small subunit 1, also known as CAPNS1, is a human gene.cite web | title = Entrez Gene: CAPNS1 calpain, small subunit 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=826| accessdate = ] PBB… …   Wikipedia

  • CAPN2 — Calpain 2, (m/II) large subunit, also known as CAPN2, is a human gene. PBB Summary section title = summary text = The calpains, calcium activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains… …   Wikipedia

  • CAPN3 — Calpain 3, (p94), also known as CAPN3, is a human gene. PBB Summary section title = summary text = Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well… …   Wikipedia

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