caldesmon
Protein originally isolated from smooth muscle (h-caldesmon; 120-150 kD on gels but 88.7 kD from sequence) also found in non-muscle cells (l-caldesmon; 70-80 kD on gels but 58.8 kD from sequence). Normally dimeric, binds to F-actin blocking the myosin binding site. Calcium-calmodulin binding to caldesmon causes its release from actin, though phosphorylation of caldesmon may also affect the link with actin. Caldesmon can block the effect of gelsolin on F-actin and will dissociate actin-gelsolin complexes and actin-profilin complexes.

Dictionary of molecular biology. 2004.

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  • Caldesmon — 1, also known as CALD1, is a human gene.cite web | title = Entrez Gene: CALD1 caldesmon 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=800| accessdate = ] Caldesmon is a calmodulin binding protein. Like… …   Wikipedia

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  • List of EC numbers (EC 3) — This list contains a list of EC numbers for the third group, EC 3, hydrolases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 3.1: Acting on Ester BondsEC… …   Wikipedia

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