- 14-3-3 proteins
Family of adapter proteins able to interact with a range of signalling molecules including c-Raf, Bcr, PI-3-kinase, polyoma middle T-antigen. Bind to phosphorylated serine residues in cdc25C and block its further activity, may bind Bad (death inducer) thereby blocking heteromeric interaction with Bcl-XL, and in plants bind and inhibit activity of phosphorylated nitrate reductase. Basic mode of action may be to block specific protein-protein interactions.
Dictionary of molecular biology. 2004.