counterscreening
Dereplication De`rep*li*ca"tion, n. (Biochem.) the process of testing samples of mixtures which are active in a screening process, so as to recognize and eliminate from consideration those active substances already studied; -- a stage subsequent to the preliminary screening in the process of discovery of new pharmacologically active substances in mixtures of natural products; -- also called {counterscreening}. See {screening}.

Note: In the process of pharmaceutical screening (testing a large number of substances to find those having desirable pharmacological activity), the testing of samples of substances extracted from living organisms (plants, microorganisms, etc.) often detects substances already detected in prior screening. Such ``known'' or ``replicate'' activities must be recognized at an early stage to avoid duplicating previous efforts at purification and structural identification. The process of testing an sample which is active in a primary screen, to determine if the activity is due to a previously known substance, is called dereplication or counterscreening. [PJC]


The Collaborative International Dictionary of English. 2000.

Look at other dictionaries:

  • counterscreening — Screening Screen ing (skr[=e]n [i^]ng), n. the process of examining or testing objects methodically to find those having desirable properties. See {screen[3]}. Note: In the pharmaceutical industry, pharmaceutical screening involves testing a… …   The Collaborative International Dictionary of English

  • Dereplication — De rep*li*ca tion, n. (Biochem.) the process of testing samples of mixtures which are active in a screening process, so as to recognize and eliminate from consideration those active substances already studied; a stage subsequent to the… …   The Collaborative International Dictionary of English

  • Screening — Screen ing (skr[=e]n [i^]ng), n. the process of examining or testing objects methodically to find those having desirable properties. See {screen[3]}. Note: In the pharmaceutical industry, pharmaceutical screening involves testing a large number… …   The Collaborative International Dictionary of English

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