rofecoxib ofecoxib (Chem. & Med.) A chemical substance ({C17H14O4S}, molecular weight 314.36) used in medicine as an analgesic to alleviate pain and inflammation; it is a synthetic compound, and is marketed by Merck & Co. under the trade name {Vioxx}, in tablets giving dosages of 12.5 or 25 milligrams. It is classed as a non-steroidal anti-inflammatory drug (NSAID). Chemically, it is 4-[4-(methylsulfony)phenyl]-3-phenyl-2(5H) furanone. Its chemical structure contains two phenyl rings and a furanone ring. It is believed to act by inhibition of prostaglandin biosynthesis, through inhibition of the enzyme cyclooxygenase-2 (COX-2); unlike {aspirin}, it does not inhibit cyclooxygenase-1. [PJC]

The Collaborative International Dictionary of English. 2000.

Look at other dictionaries:

  • Rofecoxib — Systematic (IUPAC) name 4 (4 methylsulfonylphenyl) 3 phenyl 5H furan 2 one Clinical data Pregnancy cat. C ( …   Wikipedia

  • Rofecoxib — Nombre (IUPAC) sistemático 4 (4 metilsulfonilfenil) 3 fenil 5H furan 2 ona Identificadores …   Wikipedia Español

  • Rofecoxib — Rofécoxib Rofécoxib Général No CAS …   Wikipédia en Français

  • Rofécoxib — Général Nom IUPAC 4 [4 (méthylsulfonyl)phényl] 3 phénylfuran 2(5H) one No CAS …   Wikipédia en Français

  • rofecoxib — fármaco antiinflamatorio no esteroídico inhibidor selectivo de la ciclooxigenasa Diccionario ilustrado de Términos Médicos.. Alvaro Galiano. 2010 …   Diccionario médico

  • Rofecoxib — Strukturformel Allgemeines Freiname Rofecoxib Andere Namen …   Deutsch Wikipedia

  • rofecoxib — A drug that was being used for pain relief and was being studied for its ability to prevent cancer and to block the growth of new blood vessels to solid tumors. It belongs to the family of drugs called nonsteroidal anti inflammatory drugs.… …   English dictionary of cancer terms

  • rofecoxib — noun A particular nonsteroidal anti inflammatory drug …   Wiktionary

  • rofecoxib — ro·fe·cox·ib .rō fe käk sib n a COX 2 inhibitor C17H14O4S used to relieve the signs and symptoms of osteoarthritis and rheumatoid arthritis, to manage acute pain in adults, and to treat primary dysmenorrhea but withdrawn from sale by the… …   Medical dictionary

  • rofecoxib — noun a Cox 2 inhibitor (trade name Vioxx) that relieves pain and inflammation without harming the digestive tract; voluntarily withdrawn from the market in 2004 • Syn: ↑Vioxx • Usage Domain: ↑trade name (for: ↑Vioxx) • Hypernyms: ↑ …   Useful english dictionary

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