Penicillinase Pen`i*cil"lin*ase, n. (Bioch.) an enzyme which destroys the antibacterial activity of penicillin by hydrolyzing the amide bond in the beta-lactam ring. Many penicillinases are known, and are produced by a wide variety of bacteria. The production of penicillinase is one of the mechanisms by which bacteria may become resistant to penicillins. Penicillinase production in various bacterial species may be induced, i.e., it may occur only when stimulated by the presence of penicillin in the culture medium, or it may be constitutive, i.e., it may occur whenever the cells are producing protein. Molecular weights of the various penicillinases tend to cluster near 50,000. [PJC]

The Collaborative International Dictionary of English. 2000.

Look at other dictionaries:

  • pénicillinase — ● pénicillinase nom féminin Enzyme sécrétée par diverses bactéries et capable d inactiver certains antibiotiques du groupe des pénicillines. ⇒PÉNICILLINASE, subst. fém. BIOCHIM. Enzyme produit par certains microbes et qui détruit l action de la… …   Encyclopédie Universelle

  • Penicillinase — Penicillase spaltet das Vierring Lactam (β Lactamring) eines Penicillins hydrolytisch. Die entstehende Carbonsäure decarboxyliert anschließend spontan. Penicillinase ist ein von verschiedenen Bakterien produziertes Enzym, welches in der Lage ist …   Deutsch Wikipedia

  • penicillinase — 1. SYN: β lactamase. 2. A purified enzyme preparation obtained from cultures of a strain of Bacillus cereus; formerly used in the treatment of slowly developing or delayed penicillin reactions. Used by bacteria to develop penicillin resistance. * …   Medical dictionary

  • Penicillinase — Pe|ni|cil|li|na|se [↑ Penicillin u. ↑ ase], die; , n: eine β Lactamase, die die Amidbindung der Penicilline spaltet. * * * Penicillinase   die, , von bestimmten Bakterien (u. a. Escherichia coli und einigen Staphylokokkenarten) gebildetes Enzym,… …   Universal-Lexikon

  • penicillinase — n. an enzyme, produced by some bacteria, that is capable of antagonizing the antibacterial action of penicillin and other beta lactam antibiotics. Purified penicillinase may be used to treat reactions to penicillin. It is also used in diagnostic… …   The new mediacal dictionary

  • penicillinase — noun Date: 1940 beta lactamase …   New Collegiate Dictionary

  • penicillinase — pen·i·cil·lin·ase (pĕn ĭ sĭlʹĭ nās ) n. Any of various enzymes that are produced by certain bacteria, including most strains of staphylococci, and that hydrolyze and inactivate penicillin. They are used in medicine to treat allergic reactions to… …   Universalium

  • penicillinase — noun A specific type of beta lactamase showing specificity for penicillins …   Wiktionary

  • Penicillinase — Pe|ni|cil|li|na|se 〈f.; Gen.: ; Pl.: unz.; Biochemie〉 Penicillin abbauendes Enzym, das von einigen Bakterien gebildet wird [Etym.: → Penicillin] …   Lexikalische Deutsches Wörterbuch

  • Penicillinase — Pe|ni|cil|li|na|se die; <zu ↑Penicillinu. ↑...ase> von manchen Bakterien gebildetes, Penizillin zerstörendes Enzym …   Das große Fremdwörterbuch

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”